Study of Extreme Pathways and Correlated Reaction Sets in Metabolic Networks
Author Information
Author(s): Xi Yanping, Chen Yi-Ping Phoebe, Cao Ming, Wang Weirong, Wang Fei
Primary Institution: Fudan University
Hypothesis
What is the relationship between extreme pathways and correlated reaction sets in metabolic networks?
Conclusion
Extreme pathways and correlated reaction sets are strongly related, suggesting a regulatory mechanism in metabolic networks.
Supporting Evidence
- Extreme pathways cover correlated reaction sets in an 'all or none' manner.
- Correlated reaction sets are identified for E. coli and red blood cell metabolic networks.
- Sampling was used to analyze the large-scale Saccharomyces cerevisiae metabolic network.
Takeaway
This study looks at how different pathways in cells work together. It finds that some pathways either use all reactions or none at all, which helps cells survive.
Methodology
The study used constraint-based modeling and uniform random sampling to analyze metabolic networks.
Limitations
The study may not cover all possible extreme pathways due to the computational complexity of large networks.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website