Serum Interleukin-6 Levels in Burning Mouth Syndrome Patients
Author Information
Author(s): Qianming Chen, Juan Xia, Mei Lin, Hongmei Zhou, Bingqi Li
Primary Institution: West China College of Stomatology, Sichuan University
Hypothesis
What is the relationship between serum interleukin-6 levels and clinical symptoms in burning mouth syndrome patients?
Conclusion
Serum interleukin-6 is decreased in burning mouth syndrome patients and is negatively correlated with chronic pain.
Supporting Evidence
- 31% of BMS patients displayed substantial depressive symptoms.
- HRSD scores were significantly higher in BMS patients compared to controls.
- Serum interleukin-6 levels were significantly lower in BMS patients than in healthy controls.
Takeaway
This study found that people with burning mouth syndrome have lower levels of a substance called interleukin-6, which is linked to feeling more pain.
Methodology
The study measured serum interleukin-6 levels in 48 burning mouth syndrome patients and 31 healthy controls using ELISA, and assessed depression and pain levels using HRSD and VAS.
Limitations
The study did not find significant differences in interleukin-6 levels between subgroups of patients with and without substantial depressive symptoms.
Participant Demographics
The patient group consisted of 39 females and 9 males, with a mean age of 49 years, and 69.23% were postmenopausal women.
Statistical Information
P-Value
P = .002 for HRSD and VAS correlation; P = .011 for IL-6 and VAS correlation.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website