Lipid Nanoparticles for Transdermal Delivery of Flurbiprofen
Author Information
Author(s): Bhaskar Kesavan, Anbu Jayaraman, Ravichandiran Velayutham, Venkateswarlu Vobalaboina, Rao Yamsani Madhusudan
Primary Institution: Kakatiya University
Hypothesis
The study aims to develop lipid nanoparticles for effective transdermal delivery of flurbiprofen.
Conclusion
The study found that both SLN and NLC formulations provided sustained drug release and improved bioavailability of flurbiprofen compared to oral administration.
Supporting Evidence
- The Cmax of the NLC formulation was significantly higher than that of the SLN formulation.
- The bioavailability of flurbiprofen increased by 4.4 times with the gel formulations compared to oral administration.
- Both SLN and NLC formulations showed sustained drug release over 24 hours.
Takeaway
Researchers created special tiny particles to help deliver a pain medicine through the skin, which worked better than taking it by mouth.
Methodology
The study involved preparing lipid nanoparticles, incorporating them into hydrogels, and testing their drug release and skin permeation in rats.
Limitations
The study was conducted on rats, and results may not directly translate to humans.
Participant Demographics
Adult male Wistar albino rats weighing 230-250 g were used for in vivo studies.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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