Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape
2009
Sds22 and its Role in Cell Shape and Polarity
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Grusche Felix A, Hidalgo Cristina, Fletcher Georgina, Sung Hsin-Ho, Sahai Erik, Thompson Barry J
Hypothesis
How does the Sds22 protein regulate epithelial cell morphology and polarity?
Conclusion
Sds22 is a conserved PP1 phosphatase regulatory subunit that controls cell shape and polarity.
Supporting Evidence
- Sds22 is essential for maintaining epithelial integrity in Drosophila.
- Loss of Sds22 leads to abnormal cell shapes and polarity defects.
- Sds22 regulates the phosphorylation of key proteins involved in cell shape.
- The function of Sds22 is conserved in human cells.
Takeaway
Sds22 helps cells keep their shape and stay organized, like how building blocks need to be stacked properly.
Methodology
The study used genetic screens and transgenic techniques in Drosophila to analyze the role of Sds22 in epithelial cells.
Limitations
The specific mechanisms by which Sds22 regulates cell polarity and shape were not fully elucidated.
Digital Object Identifier (DOI)
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