Dlx-2 Gene and Its Role in Cancer Cell Death
Author Information
Author(s): Lee Su Yeon, Jeon Hyun Min, Kim Cho Hee, Ju Min Kyung, Bae Hye Sun, Park Hye Gyeong, Lim Sung-Chul, Han Song Iy, Kang Ho Sung
Primary Institution: Pusan National University
Hypothesis
Dlx-2 is implicated in metabolic stress-induced necrosis in cancer cells.
Conclusion
Dlx-2 may promote tumor progression by regulating metabolic stress-induced necrosis.
Supporting Evidence
- Dlx-2 expression increases in cancer cells under glucose deprivation.
- Dlx-2 shRNA reduces necrosis and HMGB1 release in cancer cells.
- Dlx-2 is linked to mitochondrial ROS production during metabolic stress.
- Dlx-2 is expressed at higher levels in human breast cancers.
- Dlx-2 shRNA prevents necrosis in multicellular tumor spheroids.
Takeaway
Dlx-2 is a gene that helps cancer cells die when they are under stress from lack of nutrients, which can make tumors grow faster.
Methodology
The study used cDNA microarray analysis, real-time PCR, and Western blotting to investigate Dlx-2 expression in cancer cells under metabolic stress.
Limitations
The precise mechanisms of Dlx-2 regulation and its role in tumor biology remain unclear.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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