“Myc’ed Messages”: Myc induces transcription of E2F1 while inhibiting its translation via a microRNA polycistron
2007
Myc and microRNA Interactions in Cancer
publication
Evidence: moderate
Author Information
Author(s): Hilary A. Coller, Joshua J. Forman, Aster Legesse-Miller
Primary Institution: Princeton University
Hypothesis
Can the miR-17–92 microRNA cluster help cells decide between proliferation and apoptosis?
Conclusion
The miR-17–92 cluster may act as a brake on excessive proliferation and inhibit apoptosis, potentially functioning as a tumor suppressor.
Supporting Evidence
- c-myc induces the expression of the miR-17–92 cluster.
- miR-17–5p and miR-20a inhibit the translation of E2F1.
- Loss of the miR-17–92 cluster is observed in various tumors.
- Overexpression of miR-17–92 can promote proliferation and inhibit apoptosis.
Takeaway
This study looks at how a group of tiny RNA molecules can help cells decide whether to grow or die, which is important for understanding cancer.
Methodology
The study involved analyzing the interactions between c-myc, E2F transcription factors, and the miR-17–92 microRNA cluster.
Digital Object Identifier (DOI)
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