PAPC and the Wnt5a/Ror2 pathway control the invagination of the otic placode in Xenopus
2011
PAPC and the Wnt5a/Ror2 pathway control ear development in Xenopus
publication
Evidence: high
Author Information
Author(s): Barbara Jung, Almut Köhler, Alexandra Schambony, Doris Wedlich
Primary Institution: Karlsruhe Institute of Technology
Hypothesis
PAPC signaling is essential for the invagination of the otic placode during ear development.
Conclusion
PAPC signaling via RhoA and Wnt5a/Ror2 activity are required for proper cell alignment during ear placode invagination.
Supporting Evidence
- Knockdown of PAPC leads to deformation of the otic vesicle.
- Depletion of Wnt5a or Ror2 mimics the PAPC morphant phenotype.
- PAPC signaling is crucial for maintaining cell orientation during ear development.
Takeaway
PAPC helps cells in the ear to line up correctly when forming, and without it, the ear doesn't develop properly.
Methodology
Loss of function experiments using antisense morpholinos in Xenopus embryos.
Limitations
The study does not explore the long-term effects of PAPC depletion on ear function.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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