Identifying Disease Associations via Genome-Wide Association Studies
Author Information
Author(s): Huang Wenhui, Wang Pengyuan, Liu Zhen, Zhang Liqing
Primary Institution: Virginia Tech
Hypothesis
Do different diseases share common genetic associations?
Conclusion
The study found strong genetic associations between Crohn's disease, rheumatoid arthritis, and type 1 diabetes, while coronary artery disease, hypertension, and type 2 diabetes showed no such associations.
Supporting Evidence
- Crohn's disease, rheumatoid arthritis, and type 1 diabetes share genetic associations at all levels of analysis.
- Coronary artery disease, hypertension, and type 2 diabetes do not show any evidence of shared genetic basis.
- The study utilized data from the Wellcome Trust Case Control Consortium.
Takeaway
The researchers looked at seven diseases to see if they share genetic links, and they found that some diseases are more closely related than others.
Methodology
The study analyzed SNPs, genes, protein interactions, and phenotypes across seven diseases.
Limitations
The study may not have captured all hidden genetic associations due to the complexity of disease relationships.
Participant Demographics
The study involved about 2,000 individuals for each of the seven diseases and a shared set of about 3,000 controls.
Statistical Information
P-Value
10-4
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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