PEGylated Adenoviruses: From Mice to Monkeys
Author Information
Author(s): Wonganan Piyanuch, Croyle Maria A.
Primary Institution: The University of Texas at Austin
Hypothesis
Covalent modification with polyethylene glycol (PEG) can improve the pharmacokinetic, pharmacologic, and toxicologic profiles of adenoviruses used for gene therapy.
Conclusion
PEGylation of adenoviruses significantly reduces their immunogenicity and toxicity while enhancing their therapeutic efficacy.
Supporting Evidence
- PEGylation has been shown to improve the stability and solubility of biological compounds.
- PEGylated adenoviruses can evade the immune system, allowing for better gene delivery.
- Modification with PEG reduces the toxicity associated with adenoviral vectors.
Takeaway
Scientists are using a special coating called PEG to make viruses safer and more effective for treating diseases by helping them avoid the body's defenses.
Methodology
This review summarizes the history and application of PEGylation in the context of adenoviruses for gene transfer and vaccination.
Limitations
The review does not provide specific experimental data or sample sizes, limiting the ability to draw definitive conclusions.
Digital Object Identifier (DOI)
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