The Warburg Effect and Yeast Cancer Model
Author Information
Author(s): Christoph Ruckenstuhl, Sabrina Büttner, Didac Carmona-Gutierrez, Tobias Eisenberg, Guido Kroemer, Stephan J. Sigrist, Kai-Uwe Fröhlich, Frank Madeo
Primary Institution: Institute of Molecular Biosciences, University of Graz, Graz, Austria
Hypothesis
Does decreased respiration contribute to tumorigenesis in a yeast model?
Conclusion
The Warburg effect may initiate cancer formation by decreasing respiration, which suppresses apoptosis.
Supporting Evidence
- Repression of respiration in yeast cells leads to increased survival during colony development.
- Enhanced respiration triggers cell death in yeast, supporting the Warburg effect hypothesis.
- Using antioxidants like glutathione improves survival rates in yeast under respiratory stress.
Takeaway
This study shows that when yeast cells stop breathing, they can survive better and avoid dying, which might help us understand how cancer starts.
Methodology
The study used Saccharomyces cerevisiae to manipulate respiration and assess its effects on apoptosis and ROS production.
Statistical Information
P-Value
p<0.006
Statistical Significance
p<0.006
Digital Object Identifier (DOI)
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