Somatostatin Receptor Subtypes in Human Thyroid Tumors
Author Information
Author(s): Hanna Pisarek, Tomasz Stępień, Robert Kubiak, Edyta Borkowska, Marek Pawlikowski
Primary Institution: Medical University, Łódź, Poland
Hypothesis
The study aims to report the presence of all five subtypes of somatostatin receptors in surgically treated human thyroid tumors.
Conclusion
Somatostatin receptor subtypes are frequently expressed in thyroid tumors, with SSTR 1 being the dominant form.
Supporting Evidence
- SSTR 1 protein was expressed in 88.8% of investigated cases.
- SSTR 2A and 2B were both expressed in 44.4% of cases.
- SSTR 3 was found in 55.5% of cases.
- SSTR 4 was expressed in 11.2% of cases.
- SSTR 5 was expressed in 33.3% of cases.
Takeaway
This study looked at how certain receptors are found in thyroid tumors, showing that one type is very common.
Methodology
The study used immunohistochemistry and real-time PCR to assess the expression of somatostatin receptor subtypes in thyroid tumor samples.
Limitations
The study's sample size is small, which may limit the generalizability of the findings.
Participant Demographics
The study included 9 samples from 7 women and 2 men aged between 32 and 79 years.
Digital Object Identifier (DOI)
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