Clinical HBV Resistance Under Long-Term Tenofovir Therapy: A Case Report
Author Information
Author(s): Schildgen Oliver, Knud Schewe, Noah Christian, Sirma Hüseyin, Schmiedel Stefan, van Lunzen Jan, Rockstroh Jürgen Kurt
Primary Institution: Infektionsmedizinisches Centrum Hamburg (ICH St. Georg), Germany
Hypothesis
Is there emergence of clinical HBV resistance under long-term HBV combination therapy?
Conclusion
The patient experienced clinical resistance to tenofovir despite the absence of known resistance mutations.
Supporting Evidence
- The patient had a history of successful HBV treatment for over five years.
- Despite treatment, the patient developed acute hepatitis with liver failure.
- HBV DNA levels fluctuated significantly during treatment.
Takeaway
A patient treated for hepatitis B with tenofovir developed liver problems even though the virus was not detectable for years, showing that resistance can happen without mutations.
Methodology
Case report detailing the clinical history and treatment of an HIV/HBV co-infected patient.
Potential Biases
Potential bias due to the patient's history of non-adherence to treatment.
Limitations
The study is based on a single case, limiting generalizability.
Participant Demographics
44-year-old homosexual male with HIV/HBV co-infection.
Digital Object Identifier (DOI)
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