Protective Actions of PPAR-γ Activation in Renal Endothelium
2008
Protective Actions of PPAR-γ Activation in Renal Endothelium
publication
Evidence: moderate
Author Information
Author(s): Westerweel Peter E., Verhaar Marianne C.
Primary Institution: University Medical Center Utrecht
Hypothesis
PPAR-γ-agonists may favorably affect the course of renal disease through modulation of endothelial cell function.
Conclusion
PPAR-γ-agonism improves endothelial function and has direct renoprotective effects.
Supporting Evidence
- PPAR-γ-agonists stimulate nitric oxide production, improving endothelial function.
- Activation of PPAR-γ-receptors inhibits the production of endothelin-1, a vasoconstrictor.
- PPAR-γ-agonism has been shown to enhance endothelial progenitor cell function.
Takeaway
This study shows that activating a specific receptor can help protect kidney blood vessels and improve kidney health.
Methodology
The review discusses various studies on the effects of PPAR-γ-agonists on endothelial cells and renal disease.
Limitations
The review does not provide definitive evidence of PPAR-γ-agonist effects in the kidney.
Digital Object Identifier (DOI)
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