The Role of CRIPTO-1 in Melanoma
Author Information
Author(s): De Luca A, Lamura L, Strizzi L, Roma C, D'Antonio A, Margaryan N, Pirozzi G, Hsu M-Y, Botti G, Mari E, Hendrix M J C, Salomon D S, Normanno N
Primary Institution: INT-Fondazione Pascale, Naples, Italy
Hypothesis
What is the expression and functional role of CRIPTO-1 in cutaneous melanoma?
Conclusion
A significant fraction of cutaneous melanoma expresses CRIPTO-1, which is involved in the invasion and proliferation of melanoma cells.
Supporting Evidence
- 16 out of 37 primary human cutaneous melanomas expressed CRIPTO-1.
- 12 out of 21 melanoma cell lines showed CRIPTO-1 mRNA expression.
- CR-1 significantly increased the invasive ability of melanoma cells.
Takeaway
This study found that a protein called CRIPTO-1 is present in many melanoma cases and helps the cancer cells grow and spread.
Methodology
The study used immunohistochemistry, western blotting, flow cytometry, and invasion assays to assess CRIPTO-1 expression and its effects on melanoma cells.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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