Granisetron vs. Metoclopramide for Preventing Nausea from Cisplatin
Author Information
Author(s): B. Chevallier, The Granisetron Study Group
Primary Institution: Centre Henri Becquerel, Rouen Cedex, France
Hypothesis
Is granisetron as effective as a combination of high-dose metoclopramide and dexamethasone in preventing cisplatin-induced nausea and vomiting?
Conclusion
Granisetron is as effective as the combination regimen for preventing nausea and vomiting caused by cisplatin, with fewer side effects.
Supporting Evidence
- 70% of patients treated with granisetron were complete responders, compared to 67% in the comparator group.
- Granisetron had a lower incidence of extrapyramidal reactions compared to the comparator group.
- Headache was the most common side effect in the granisetron group, occurring in 9.8% of patients.
Takeaway
This study found that a single dose of granisetron can help stop patients from feeling sick after chemotherapy, just like a more complicated treatment that takes longer to give.
Methodology
A single-blind, multicentre study comparing granisetron with a combination of high-dose metoclopramide and dexamethasone in patients receiving cisplatin chemotherapy.
Potential Biases
Potential bias due to the single-blind design and the subjective nature of patient-reported outcomes.
Limitations
The study was single-blind, which may introduce bias, and it only included patients receiving cisplatin for the first time.
Participant Demographics
{"total_patients":281,"male":183,"female":98,"mean_age":56.6,"race":{"caucasian":272,"other":9}}
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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