C-Xyloside Boosts Skin Cell Growth and Movement
Author Information
Author(s): Muto Jun, Naidu Nandita Natasha, Yamasaki Kenshi, Pineau Nathalie, Breton Lionel, Gallo Richard L.
Primary Institution: University of California, San Diego
Hypothesis
Can a C-Xylopyranoside derivative promote dermatan sulfate production and enhance keratinocyte responses to FGF-10?
Conclusion
C-Xyloside significantly increases the production of dermatan sulfate in keratinocytes, enhancing their migration and proliferation in response to FGF-10.
Supporting Evidence
- C-Xyloside treatment led to a significant increase in the secretion of sulfated glycosaminoglycans.
- The majority of the induced glycosaminoglycan was identified as dermatan sulfate.
- Keratinocytes treated with C-Xyloside showed enhanced migration in response to FGF-10.
- Conditioned media from C-Xyloside-treated keratinocytes facilitated FGF-10-dependent cell proliferation.
Takeaway
This study shows that a special sugar can help skin cells grow and move better, which is important for healing wounds.
Methodology
Normal human epidermal keratinocytes were treated with C-Xyloside, and the secretion of sulfated glycosaminoglycans was measured over time.
Potential Biases
Potential conflicts of interest due to funding from L'Oréal, which may influence study outcomes.
Limitations
The study primarily focuses on in vitro results, and further in vivo studies are needed to confirm the findings.
Participant Demographics
Normal human epidermal keratinocytes were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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