Fructose's Effect on Heart Cell Function
Author Information
Author(s): Mellor Kimberley M., Bell James R., Wendt Igor R., Davidoff Amy J., Ritchie Rebecca H., Delbridge Lea M. D.
Primary Institution: University of Melbourne
Hypothesis
Can fructose modulate cardiomyocyte excitation-contraction coupling in an acute, in vitro setting?
Conclusion
Fructose can influence heart cell function by modulating contraction and relaxation phases.
Supporting Evidence
- Fructose supplementation reversed the prolongation of twitch timecourse induced by glucose metabolic inhibition.
- Cardiomyocytes expressed the fructose transporter GLUT5, indicating a mechanism for fructose uptake.
- Fructose improved the time to peak Ca2+ transient compared to glucose metabolic inhibition.
Takeaway
This study shows that fructose can help heart cells work better when glucose is not available.
Methodology
Isolated adult rat cardiomyocytes were used to evaluate the effects of fructose on contractility and Ca2+ handling under controlled conditions.
Limitations
The study was conducted in vitro, and the effects of long-term fructose exposure were not assessed.
Participant Demographics
Adult male Sprague Dawley rats were used for cardiomyocyte isolation.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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