Regenerating Gene Iα Overexpression in Atrophic Gastritis Rats
Author Information
Author(s): Chen Shujie, Zhong Jing, Zhou Qunyan, Lu Xiaofeng, Wang Liangjing, Si Jianmin
Primary Institution: Laboratory of Digestive Disease, Sir Run Run Shaw Clinical Medicine Institution of Zhejiang University
Hypothesis
The role of gastrin on the development of atrophic gastritis and its relationship with the expression of RegIα in vivo remain unclear.
Conclusion
The study demonstrated that RegIα overexpression is related to hypergastrinemia in atrophic gastritis rats.
Supporting Evidence
- The mean score of inflammation in AG rats was significantly elevated.
- The number of gastric glands dramatically decreased in AG rats.
- Cell proliferation in gastric glands was increased in experimental AG rats.
- Serum gastrin levels were significantly elevated in AG rats compared to normal rats.
- RegIα protein expression was higher in AG rats than in normal control rats.
Takeaway
The researchers studied rats with stomach inflammation and found that a specific protein, RegIα, was produced more when there was too much gastrin, a hormone that helps digestion.
Methodology
The study involved establishing atrophic gastritis in rats through specific chemical administration and assessing inflammation and protein expression.
Participant Demographics
Twenty male Wistar rats aged 130–150g were used in the study.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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