Selectivity in C-alkylation of dianions of protected 6-methyluridine
2011
Selective C-alkylation of Uridine Derivatives
publication
Evidence: moderate
Author Information
Author(s): Nguyen Ngoc Hoa, Len Christophe, Castanet Anne-Sophie, Mortier Jacques, Snieckus Victor
Primary Institution: Université du Maine and CNRS
Hypothesis
Can we achieve regioselective synthesis of 6-ω-alkenyluridines from protected uridine derivatives?
Conclusion
A new method for synthesizing 6-ω-alkenyluridines from protected uridine has been successfully developed.
Supporting Evidence
- The method allows for regioselective chain-extension procedures.
- Sequential treatment with LTMP or LDA followed by alkylation was effective.
- The study provides a new approach to synthesize antiviral and antitumor compounds.
Takeaway
The researchers found a way to make special types of uridine that could help create new medicines by using a clever chemical process.
Methodology
The study involved sequential lithiation and alkylation of protected uridine derivatives using specific reagents and conditions.
Digital Object Identifier (DOI)
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