Cost Effectiveness of HPV Vaccination in the UK
Author Information
Author(s): Jit Mark, Choi Yoon Hong, Edmunds W John
Primary Institution: Health Protection Agency, London
Hypothesis
To assess the cost effectiveness of routine vaccination of 12 year old schoolgirls against human papillomavirus infection in the United Kingdom.
Conclusion
Routine vaccination of 12 year old schoolgirls combined with an initial catch-up campaign up to age 18 is likely to be cost effective in the UK.
Supporting Evidence
- Vaccinating 12 year old schoolgirls with a quadrivalent vaccine at 80% coverage is likely to be cost effective.
- Implementing a catch-up campaign of girls up to age 18 is likely to be cost effective.
- Vaccination of boys is unlikely to be cost effective.
Takeaway
Vaccinating 12-year-old girls against HPV is a good idea because it can save money and help prevent cancer and warts.
Methodology
A transmission dynamic model was used to predict the burden of HPV-related disease and assess the cost effectiveness of various vaccination strategies.
Potential Biases
Potential biases may arise from the assumptions made in the model regarding vaccine efficacy and population behavior.
Limitations
The model does not account for all biological uncertainties and assumes that the screening program will continue unchanged.
Participant Demographics
Schoolgirls aged 12 or older in the UK.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% range £13,800-£32,900
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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