Study of Essential Oils from Ammodaucus leucotrichus and Perillaldehyde's Effects on Intestinal Contractions
Author Information
Author(s): Karim Ahmed, Marghich Mohamed, Amrani Ouafa, Addous Abdelhay, Malek Sanae, Beyi Leila, Harit Tarik, Aldisi Dara, Aboul-Soud Mourad A. M., Giesy John P., Aziz Mohammed
Primary Institution: Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Oujda, Morocco
Hypothesis
The study aims to verify the traditional use of Ammodaucus leucotrichus essential oil by assessing its relaxant and spasmolytic activities.
Conclusion
Ammodaucus leucotrichus essential oil exhibits myorelaxant and antispasmodic effects, attributed to its main component, perillaldehyde.
Supporting Evidence
- Perillaldehyde was found to be the major component of the essential oil, constituting 91.12% of its composition.
- The IC50 values for the relaxant effects of ALEO and perillaldehyde were 158.68 ± 13.89 and 95.03 ± 0.93 μg/mL, respectively.
- ALEO demonstrated a dose-dependent spasmolytic effect on jejunum contractions induced by carbachol and potassium chloride.
- Perillaldehyde exhibited a low degree of in silico acute toxicity and high intestinal absorption rate of 97.2%.
- The study provides scientific support for the traditional use of A. leucotrichus in treating gastrointestinal disorders.
Takeaway
This study shows that a plant oil can help relax the muscles in your tummy, which might help with stomach aches.
Methodology
The study involved in vitro evaluations of the essential oil's effects on isolated rat and rabbit jejunum using organ baths and GC/MS analysis.
Participant Demographics
Wistar rats and New Zealand rabbits of both sexes were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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