Comparative Study of Protein Kinases in Humans and Chimpanzees
Author Information
Author(s): Anamika Krishanpal, Martin Juliette, Srinivasan Narayanaswamy
Primary Institution: Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
Hypothesis
The study aims to identify and analyze the differences in protein kinases between humans and chimpanzees.
Conclusion
Despite the close evolutionary relationship, there are significant differences in the functions of chimpanzee kinases compared to human kinases.
Supporting Evidence
- The study identified 587 putative protein kinases in the chimpanzee genome.
- It was found that 160 chimpanzee kinases have no close human orthologue with greater than 95% sequence identity.
- The analysis revealed unique domain architectures in chimpanzee kinases compared to human kinases.
Takeaway
This study looks at the proteins that help cells communicate and grow in humans and chimpanzees, showing that even closely related species can have important differences.
Methodology
The study used bioinformatics approaches to identify and classify putative protein kinases in the chimpanzee genome and compared them with human kinases.
Limitations
The study is limited to recognizing kinases that are common and different between human and chimpanzee, and does not explore other species.
Digital Object Identifier (DOI)
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