Jaagsiekte Sheep Retrovirus and Lung Cancer in Sheep
Author Information
Author(s): Hofacre Andrew, Fan Hung
Primary Institution: University of California, Irvine
Hypothesis
JSRV is the causative agent of ovine pulmonary adenocarcinoma (OPA) and its envelope protein functions as an oncogene.
Conclusion
JSRV is an acute transforming retrovirus that induces lung cancer in sheep through its envelope protein.
Supporting Evidence
- JSRV is found in sheep across multiple continents, indicating its widespread impact.
- OPA accounts for nearly 70% of all sheep tumors in the U.K. and South Africa.
- Filtered lung fluid from infected sheep can reproduce the disease in healthy sheep.
Takeaway
A virus called JSRV makes sheep sick with lung cancer, and it does this by changing how their cells grow.
Methodology
The study involved molecular cloning, transformation assays in cell lines, and animal models to demonstrate the oncogenic potential of JSRV.
Limitations
The study primarily focuses on sheep and may not directly translate to human lung cancer mechanisms.
Participant Demographics
The study involved sheep, specifically those affected by ovine pulmonary adenocarcinoma.
Digital Object Identifier (DOI)
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