Homocysteine Metabolism Genes and Type 2 Diabetes Risk in Indians
Author Information
Author(s): Ganesh Chauhan, Ismeet Kaur, Rubina Tabassum, Om Prakash Dwivedi, Saurabh Ghosh, Nikhil Tandon, Dwaipayan Bharadwaj
Primary Institution: CSIR-Institute of Genomics and Integrative Biology
Hypothesis
The study evaluates the association of common variants of genes involved in homocysteine metabolism with type 2 diabetes and related traits in North Indians.
Conclusion
The study found suggestive evidence for the association of homocysteine metabolism gene variants with type 2 diabetes, but these associations were not confirmed upon replication.
Supporting Evidence
- The variant MTHFR-rs1801133 showed the strongest association with type 2 diabetes in the initial phase.
- Associations with other traits like HDL-C and total cholesterol were also observed but not replicated.
- Meta-analysis failed to confirm the association of MTHFR-rs1801133 with type 2 diabetes.
Takeaway
The researchers looked at how certain genes related to homocysteine might affect the risk of diabetes in Indian people, but they couldn't prove it for sure.
Methodology
The study involved genotyping 90 variants in two phases with a total of 4215 subjects, including type 2 diabetes patients and nondiabetic controls.
Potential Biases
Potential population stratification and dietary differences may have influenced the results.
Limitations
The associations could not be replicated in the second phase, indicating the need for larger studies across different ethnic groups.
Participant Demographics
Participants were unrelated, urban dwellers of Indo-European ethnicity from North India.
Statistical Information
P-Value
0.003
Confidence Interval
0.67–0.92
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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