The Dual Role of p53 in Fighting Viruses
Author Information
Author(s): Carmen Rivas, Stuart A. Aaronson, Cesar Munoz-Fontela
Primary Institution: Centro Nacional de Biotecnologia, CSIC
Hypothesis
p53 plays a key role in antiviral innate immunity by inducing apoptosis and enforcing the type I interferon response.
Conclusion
p53 contributes to antiviral immunity by both promoting apoptosis in infected cells and enhancing the type I interferon response.
Supporting Evidence
- p53 is activated by type I interferons during viral infections.
- p53 induces apoptosis in infected cells, limiting virus replication.
- Several genes involved in antiviral responses are direct targets of p53.
Takeaway
p53 is like a superhero for our cells, helping them fight off viruses by making sick cells self-destruct and boosting the body's defenses.
Methodology
The review summarizes recent findings on p53's role in antiviral immunity, focusing on its interactions with type I interferons and apoptosis.
Limitations
The complexity of p53's role in different cell types and its interactions with various viruses complicates the understanding of its functions.
Digital Object Identifier (DOI)
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