SEPS1 Gene Polymorphism and Gastric Cancer Risk
Author Information
Author(s): Shibata Tomoyuki, Arisawa Tomiyasu, Tahara Tomomitsu, Ohkubo Masaaki, Yoshioka Daisuke, Maruyama Naoko, Fujita Hiroshi, Kamiya Yoshio, Nakamura Masakatsu, Nagasaka Mitsuo, Iwata Masami, Takahama Kazuya, Watanabe Makoto, Hirata Ichiro
Primary Institution: Fujita Health University, School of Medicine
Hypothesis
The -105G>A polymorphism in the SEPS1 gene influences the susceptibility to gastric cancer in the Japanese population.
Conclusion
The -105G>A polymorphism of SEPS1 is associated with an increased risk of intestinal type gastric cancer.
Supporting Evidence
- The A allele was associated with increased odds of gastric cancer compared to the GG genotype.
- Carrying the A allele was significantly associated with increased risks of intestinal type gastric cancer.
- The study included a large sample size of gastric cancer patients and controls.
Takeaway
A specific change in a gene related to inflammation may make some people more likely to get a type of stomach cancer.
Methodology
The study involved stomach biopsies from gastric cancer patients and controls, with DNA extracted for genotyping the SEPS1 polymorphism using PCR-RFLP methods.
Limitations
The study's findings may not be generalizable due to the specific population studied and the rarity of the AA genotype.
Participant Demographics
268 gastric cancer patients (193 males, 75 females, average age 65.3) and 306 control patients (184 males, 122 females, average age 62.7).
Statistical Information
P-Value
0.07
Confidence Interval
1.0–4.1
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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