Extramedullary leukemia in children with proptosis
Author Information
Author(s): Murthy Ramesh, Vemuganti Geeta K, Honavar Santosh G, Naik Milind, Reddy Vijayanand
Primary Institution: L V Prasad Eye Institute, Hyderabad, India
Hypothesis
Can a peripheral blood smear help diagnose acute myeloid leukemia in children presenting with proptosis?
Conclusion
A peripheral blood smear should be performed in all cases of sudden onset proptosis or an orbital mass in children and young adults.
Supporting Evidence
- All patients presented with proptosis.
- A diagnosis of acute myeloid leukemia was established by incision biopsy in 4 patients.
- In 8 patients, diagnosis was established by peripheral blood smear examination alone.
Takeaway
If a child has a bulging eye, doctors should check their blood to see if they have a type of blood cancer called leukemia.
Methodology
A retrospective review of records of patients with orbital manifestations of acute myeloid leukemia.
Limitations
The study is limited to a small sample size and retrospective design.
Participant Demographics
Median age at presentation was 6 years, with a male to female ratio of 0.7:1.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website