CRMP5 Regulates Generation and Survival of Newborn Neurons in the Adult Mouse Brain
Author Information
Author(s): Veyrac Alexandra, Reibel Sophie, Sacquet Joëlle, Mutin Mireille, Camdessanche Jean-Philippe, Kolattukudy Pappachan, Honnorat Jérôme, Jourdan François
Primary Institution: Lyon Neuroscience Research Center, Université de Lyon - Université Claude Bernard Lyon 1
Hypothesis
What is the role of CRMP5 in neurogenesis in the adult mouse brain?
Conclusion
CRMP5 is involved in the generation and survival of newly generated neurons in the adult brain's neurogenic areas.
Supporting Evidence
- CRMP5 is expressed in proliferating and post-mitotic neuroblasts in the adult brain.
- CRMP5 knockout mice showed increased neurogenesis but also higher rates of neuronal apoptosis.
- The study found that CRMP5 negatively regulates the proliferation of neural progenitors.
Takeaway
CRMP5 helps control how many new brain cells are made and how long they live, which is important for brain health.
Methodology
The study used CRMP5 knockout mice to assess the effects on neurogenesis and cell survival in the olfactory bulb and dentate gyrus.
Limitations
The study primarily focused on two neurogenic areas and may not generalize to other brain regions.
Participant Demographics
Adult male mice, specifically 12-week-old.
Statistical Information
P-Value
p=0.008
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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