Improving Adenovirus Based Gene Transfer: Strategies to Accomplish Immune Evasion
Author Information
Author(s): Seregin Sergey S., Amalfitano Andrea
Primary Institution: Michigan State University
Hypothesis
Can strategies to counteract immune responses improve the efficacy of adenovirus-based gene transfer?
Conclusion
Developing strategies to evade immune responses can enhance the effectiveness of adenovirus-based gene transfer.
Supporting Evidence
- Adenovirus vectors are increasingly used in clinical trials, indicating their growing acceptance.
- Strategies to modify the adenovirus can help reduce immune responses and improve gene transfer outcomes.
- Pre-existing immunity to adenoviruses can limit the effectiveness of gene therapy.
Takeaway
This study looks at ways to help adenoviruses deliver genes better by avoiding the body's immune system, which can attack them.
Methodology
The review discusses various strategies for immune evasion in adenovirus-based gene transfer, including immune modulation and vector modification.
Potential Biases
Potential bias due to the focus on specific strategies without comprehensive evaluation of all possible approaches.
Limitations
The review primarily focuses on preclinical studies and lacks extensive clinical trial data.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website