Vitamin K Status in Spaceflight and Ground-Based Models of Spaceflight
Author Information
Author(s): Zwart Sara R, Booth Sarah L, Peterson James W, Wang Zuwei, Smith Scott M
Primary Institution: NASA Johnson Space Center
Hypothesis
Does vitamin K status change in response to microgravity during spaceflight and in ground-based analogs?
Conclusion
The study found no significant changes in vitamin K status during spaceflight or bed rest, suggesting that vitamin K supplementation is not needed as a countermeasure for bone loss in spaceflight.
Supporting Evidence
- Vitamin K levels were stable in astronauts during long-duration flights.
- Bed rest studies showed no significant changes in vitamin K status.
- Urinary GLA and undercarboxylated osteocalcin did not indicate a need for vitamin K supplementation.
Takeaway
The astronauts' vitamin K levels didn't change much during their time in space, so they probably don't need extra vitamin K to keep their bones healthy.
Methodology
The study measured vitamin K status through blood and urine samples collected from astronauts during and after spaceflight, as well as from participants in bed rest studies.
Limitations
The study did not have dietary intake data available during flight, which could affect vitamin K status.
Participant Demographics
15 astronauts (11 male, 4 female) and participants in various bed rest studies.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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