RNA Editing and its Control in Hepatitis Delta Virus Replication
2010
RNA Editing in Hepatitis Delta Virus Replication
publication
Evidence: moderate
Author Information
Author(s): Chen Renxiang, Linnstaedt Sarah D., Casey John L.
Primary Institution: Georgetown University Medical Center
Hypothesis
How does RNA editing influence the replication cycle of the hepatitis delta virus?
Conclusion
RNA editing is crucial for the hepatitis delta virus replication cycle, affecting the production of its proteins and the overall virus output.
Supporting Evidence
- HDAg-S is required for RNA replication, while HDAg-L inhibits replication.
- Editing occurs on the antigenome, which is a replication intermediate.
- Optimal production of infectious virus requires control of editing.
Takeaway
The hepatitis delta virus uses a special process called RNA editing to make different versions of its proteins, which helps it replicate and spread.
Methodology
This review analyzes the mechanisms and control of RNA editing in the hepatitis delta virus replication cycle.
Limitations
The review does not provide experimental data but summarizes existing literature.
Digital Object Identifier (DOI)
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