Correlations Among Depression Rating Scales
Author Information
Author(s): Jiang Qin, Ahmed Saeeduddin
Primary Institution: Wyeth Research
Hypothesis
This analysis aimed to assess correlations among the HAM-D17, MADRS, CGI-S, and CGI-I scales in clinical trials of venlafaxine for major depressive disorder.
Conclusion
The study found that while MADRS and CGI-I were more sensitive to treatment effects, all four scales provided a consistent picture of response to venlafaxine treatment.
Supporting Evidence
- The HAM-D17, MADRS, CGI-S, and CGI-I scales were all significantly correlated at all time points.
- Effect sizes for the continuous outcomes ranged from 0.31 to 0.42.
- MADRS and CGI-I were better at detecting treatment differences compared to HAM-D17 or CGI-S.
Takeaway
The study looked at how different tests for depression relate to each other when patients take a medicine called venlafaxine. They found that all tests showed similar results.
Methodology
Data from 22 double-blind, placebo-controlled studies were analyzed, focusing on correlations between four depression rating scales.
Potential Biases
Potential bias may arise from different clinicians performing assessments, which could affect correlation results.
Limitations
The variability among studies in terms of diagnostic criteria and treatment regimens may affect the generalizability of the results.
Participant Demographics
Adult patients with major depressive disorder, including both outpatients and inpatients.
Statistical Information
P-Value
0.0001
Statistical Significance
p < 0.0001
Digital Object Identifier (DOI)
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