Parathyroid hormone, but not vitamin D, is associated with the metabolic syndrome in morbidly obese women and men: a cross-sectional study
2009

Parathyroid Hormone and Metabolic Syndrome in Obese Patients

Sample size: 1017 publication Evidence: moderate

Author Information

Author(s): Jøran Hjelmesæth, Dag Hofsø, Erlend T. Aasheim, Trond Jenssen, Johan Moan, Helle Hager, Jo Røislien, Jens Bollerslev

Primary Institution: Morbid Obesity Center, Vestfold Hospital Trust, Health Region South, Tønsberg, Norway

Hypothesis

Is metabolic syndrome associated with abnormal serum levels of parathyroid hormone, vitamin D, and magnesium in morbidly obese patients?

Conclusion

Parathyroid hormone levels, but not vitamin D levels, are independent predictors of metabolic syndrome in morbidly obese individuals.

Supporting Evidence

  • 68% of the patients had metabolic syndrome.
  • Patients with metabolic syndrome had lower mean serum magnesium and higher mean PTH than those without.
  • PTH levels in the second to fourth quartiles were associated with higher odds of metabolic syndrome.

Takeaway

This study found that higher levels of a hormone called parathyroid hormone are linked to a higher chance of having metabolic syndrome in very overweight people.

Methodology

Fasting serum levels of 25(OH)D, PTH, and magnesium were assessed in a cross-sectional cohort study of 1,017 consecutive morbidly obese patients.

Potential Biases

Potential selection bias due to referral to a tertiary care center.

Limitations

The cross-sectional design limits the ability to establish cause-effect relationships, and results may not be valid in non-white populations.

Participant Demographics

68% women, Caucasian morbidly obese patients.

Statistical Information

P-Value

0.001

Confidence Interval

95% CI 1.52–4.53

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.1186/1475-2840-8-7

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