Mapping Genes for Marek's Disease Resistance in Chickens
Author Information
Author(s): Heifetz Eliyahu M, Fulton Janet E, O'Sullivan Neil P, Arthur James A, Cheng Hans, Wang Jing, Soller Morris, Dekkers Jack CM
Primary Institution: Iowa State University
Hypothesis
The study aims to identify quantitative trait loci (QTL) associated with resistance to Marek's disease in chickens.
Conclusion
The study identified 21 QTL regions associated with Marek's disease resistance, suggesting that resistance alleles are likely recessive.
Supporting Evidence
- Twenty-one QTL regions affecting post-challenge survival time were identified across 11 chromosomes.
- About two-thirds of the MD resistance alleles were derived from the more resistant parental line.
- Eight of the QTL regions were previously identified in a backcross mapping study.
Takeaway
Researchers looked at chickens to find genes that help them resist a disease called Marek's disease, and they found many important genes.
Methodology
The study used a full-sib intercross population and phenotyped chickens for survival time after exposure to Marek's disease virus, along with selective DNA pooling for QTL mapping.
Potential Biases
Potential bias due to the specific genetic backgrounds of the chicken lines used.
Limitations
The study's findings may not be generalizable beyond the specific chicken lines studied.
Participant Demographics
The study involved commercial layer chickens from two partially inbred lines.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website