Impact of the Genome on the Epigenome in Twins
Author Information
Author(s): Coolen Marcel W., Statham Aaron L., Qu Wenjia, Campbell Megan J., Henders Anjali K., Montgomery Grant W., Martin Nick G., Clark Susan J.
Primary Institution: Garvan Institute of Medical Research
Hypothesis
How does the genome influence DNA methylation patterns in monozygotic and dizygotic twins?
Conclusion
The study shows that while DNA methylation states are generally similar between genetically identical individuals, significant variability exists that may affect disease susceptibility.
Supporting Evidence
- DNA methylation levels were significantly correlated within imprinted regions.
- MZ twins showed less discordance in methylation levels compared to DZ twins.
- Specific SNPs were associated with increased methylation in the H19 region.
Takeaway
Even identical twins can have different DNA methylation patterns, which might affect their health.
Methodology
DNA methylation levels were analyzed in 256 pairs of monozygotic and dizygotic twins using mass spectrometry.
Potential Biases
Potential bias from environmental factors affecting DNA methylation was not fully controlled.
Limitations
The study primarily focuses on specific imprinted regions and may not generalize to all genomic regions.
Participant Demographics
The sample consisted of 512 adolescent twins, predominantly of northern European origin.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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