Ketogenic Diets and Exogenous Ketones for Neurodevelopmental Disorders
Author Information
Author(s): Omori Naomi Elyse, Malys Mantas Kazimieras, Woo Geoffrey, Mansor Latt
Primary Institution: Health Via Modern Nutrition Inc. (H.V.M.N.), San Francisco, CA, United States
Hypothesis
Can the ketogenic diet and exogenous ketone bodies be effective treatments for neurodevelopmental disorders like autism and ADHD?
Conclusion
The current literature suggests that while ketogenic interventions show promise for neurodevelopmental disorders, more comprehensive clinical studies are needed to establish their effectiveness.
Supporting Evidence
- 14 preclinical and 10 clinical studies were included for discussion.
- Data supporting the use of a ketogenic intervention for neurodevelopmental disorders is mixed.
- High heterogeneity in study design was noted for preclinical models, ketogenic intervention, and outcomes measured.
Takeaway
This study looks at how a special diet called the ketogenic diet might help kids with autism and ADHD. It finds that while some kids did better on this diet, we need more research to be sure.
Methodology
A narrative review of existing literature on the ketogenic diet and exogenous ketone supplementation for treating neurodevelopmental disorders.
Potential Biases
Potential biases due to the lack of control groups and reliance on self-reported outcomes.
Limitations
The studies reviewed had small sample sizes, lacked blinding, and varied in dietary protocols.
Participant Demographics
Children aged 2-21 with a confirmed diagnosis of ASD.
Statistical Information
P-Value
0.025
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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