Lipid Membranes in Poxvirus Replication
2010
Lipid Membranes in Poxvirus Replication
publication
Evidence: moderate
Author Information
Author(s): Laliberte Jason P., Moss Bernard
Primary Institution: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Conclusion
Lipoprotein membranes play crucial roles in the poxvirus life cycle, including entry, assembly, and spread.
Supporting Evidence
- Poxviruses replicate in the cytoplasm and acquire multiple lipoprotein membranes.
- The mature virion consists of a viral DNA genome encased in a protein core and an outer lipoprotein membrane.
- Entry of the viral core into the cytoplasm initiates the poxvirus life cycle.
- Assembly of the mature virion involves more than 80 viral gene products.
Takeaway
Poxviruses use special membranes to enter cells and make new virus particles, which helps them spread.
Digital Object Identifier (DOI)
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