Understanding How HTLV-1 Enters Cells
Author Information
Author(s): Jones Kathryn S., Lambert Sophie, Bouttier Manuella, Bénit Laurence, Ruscetti Frank W., Hermine Olivier, Pique Claudine
Primary Institution: Basic Science Program, SAIC-Frederick, Inc., NCI-Frederick, Maryland, USA
Hypothesis
What are the functional domains of the HTLV-1 surface subunit and how do they relate to entry receptors?
Conclusion
HTLV-1 entry into cells involves a multi-receptor model with interactions between the viral envelope protein and specific host cell receptors.
Supporting Evidence
- HTLV-1 entry requires interactions with GLUT1, NRP-1, and HSPGs.
- NRP-1 and GLUT1 form a stable complex with the HTLV-1 surface subunit.
- HSPGs are essential for the initial binding of HTLV-1 to target cells.
- Different HTLV viruses may use different receptor complexes for entry.
Takeaway
HTLV-1 uses three helpers to get into cells: one helps it stick, another helps it grab on, and the last one helps it get inside.
Methodology
The review summarizes previous studies on HTLV-1 entry mechanisms and receptor interactions.
Limitations
The review does not provide new experimental data but synthesizes existing knowledge.
Digital Object Identifier (DOI)
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