Adenoviral Producer Cells
2010
Adenoviral Producer Cells
publication
Evidence: moderate
Author Information
Author(s): Kovesdi Imre, Hedley Susan J.
Primary Institution: VectorLogics, Inc.
Conclusion
The review discusses various producer cell lines for adenoviral vectors, highlighting their advantages and limitations in gene therapy applications.
Supporting Evidence
- Adenoviral vectors are modified to prevent replication and require specific producer cell lines for effective production.
- HEK293 cells are commonly used but have risks of contamination with replication-competent adenovirus.
- Newer cell lines like PER.C6 are developed to improve safety and efficiency in adenoviral vector production.
Takeaway
This study looks at different types of cells used to make adenoviruses for medicine, explaining how they help produce safe and effective treatments.
Methodology
The review summarizes the development and characteristics of various adenoviral producer cell lines, including HEK293, PER.C6, and others.
Limitations
Some cell lines have issues with contamination and licensing, which can limit their use in research and production.
Digital Object Identifier (DOI)
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