SpliceCenter: Web Tools for Analyzing Alternative Splicing
Author Information
Author(s): Ryan Michael C, Zeeberg Barry R, Caplen Natasha J, Cleland James A, Kahn Ari B, Liu Hongfang, Weinstein John N
Primary Institution: National Cancer Institute, National Institutes of Health
Hypothesis
How does alternative splicing impact the interpretation of biological assays?
Conclusion
SpliceCenter provides unique, user-friendly applications for assessing the impact of transcript variation on various biological assays.
Supporting Evidence
- SpliceCenter tools provide visualizations of a gene's alternative transcripts.
- 59% of shRNAs in a large-scale library target all known splice variants.
- The tools are designed for both bench biologists and bioinformaticists.
Takeaway
SpliceCenter is a set of online tools that helps scientists understand how different versions of genes can affect their experiments.
Methodology
Development of web-based applications for analyzing the impact of splice variation on various biological assays.
Limitations
The tools may not cover all possible splice variants and are limited to the data available in the databases used.
Digital Object Identifier (DOI)
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