Cystatin C and Heart Health
Author Information
Author(s): Subhashish Agarwal, Vinay Thohan, Michael G. Shlipak, Joao Lima, David A. Bluemke, David Siscovick, Antoinette Gomes, David M. Herrington
Primary Institution: Wake Forest University
Hypothesis
Cystatin C is a marker for ventricular remodeling, independent of blood pressure, in a multi-ethnic population.
Conclusion
Cystatin C levels were inversely associated with left ventricular end-diastolic and end-systolic volumes and directly associated with concentricity in a multi-ethnic population.
Supporting Evidence
- Cystatin C levels were inversely associated with LVEDV and LVESV.
- The study included a large, ethnically diverse population.
- Associations remained significant after adjusting for traditional cardiovascular risk factors.
Takeaway
Cystatin C is a blood marker that can help us understand heart health, especially how the heart changes shape and size when the kidneys aren't working well.
Methodology
The study analyzed cystatin C levels and left ventricular parameters using MRI in a diverse cohort from the MESA study.
Potential Biases
Potential for residual confounding due to unmeasured variables.
Limitations
The study's cross-sectional design limits causal inferences, and it did not directly measure glomerular filtration rate.
Participant Demographics
Participants were racially diverse, aged 44-84, with 38% Caucasian, 28% African-American, 22% Hispanic, and 12% Chinese.
Statistical Information
P-Value
P = 0.0001 for LVEDV, P = 0.04 for LVESV
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website