Effectiveness of Malaria Treatments in Mali
Author Information
Author(s): Tekete Mamadou, Djimde Abdoulaye A, Beavogui Abdoul H, Maiga Hamma, Sagara Issaka, Fofana Bakary, Ouologuem Dinkorma, Dama Souleymane, Kone Aminatou, Dembele Demba, Wele Mamadou, Dicko Alassane, Doumbo Ogobara K
Primary Institution: Malaria Research and Training Center/Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto-Stomatology, Bamako, Mali
Hypothesis
What is the efficacy of chloroquine, amodiaquine, and sulphadoxine-pyrimethamine for treating uncomplicated falciparum malaria in Mali?
Conclusion
Sulphadoxine-pyrimethamine was found to be the most effective treatment for uncomplicated falciparum malaria, followed by amodiaquine.
Supporting Evidence
- ACPR rates for chloroquine were low, indicating resistance.
- Amodiaquine showed the highest effectiveness on fever.
- Sulphadoxine-pyrimethamine had the highest clinical response rates after molecular correction.
Takeaway
This study looked at how well different malaria medicines work in kids. It found that one medicine worked the best.
Methodology
Children aged 6 to 59 months with uncomplicated malaria were randomly assigned to receive one of three treatments, and their responses were monitored over 28 days.
Potential Biases
Potential biases may arise from the open-label design and randomization process.
Limitations
The study was limited to a specific geographic area and may not be generalizable to other regions.
Participant Demographics
Children aged 6 to 59 months from Kolle, Mali.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website