Study on Graft Patency in Off-Pump vs On-Pump Coronary Bypass Surgery
Author Information
Author(s): Uva Miguel Sousa, Matias Fernando, Cavaco Sara, Magalhães Manuel Pedro
Primary Institution: Hospital da Cruz Vermelha, Lisboa, Portugal
Hypothesis
Coronary artery bypass grafting (CABG) performed without cardiopulmonary bypass (Off-Pump) has equivalent early graft patency as if performed with cardiopulmonary bypass (On-Pump) and may have reduced complication rate.
Conclusion
The PROMISS trial aims to provide insights into the effects of Off-Pump compared to On-Pump coronary artery bypass surgery on graft patency.
Supporting Evidence
- The study includes patients with multi-vessel disease requiring at least three grafts.
- It aims to compare the effectiveness of two surgical techniques in a randomized manner.
- The use of multidetector computed tomography allows for non-invasive assessment of graft patency.
Takeaway
This study is trying to find out if heart surgery done without a heart-lung machine works just as well as surgery done with it.
Methodology
A controlled, single blinded, single centre clinical trial comparing early graft patency using 16-slice computed tomography in patients with multi-vessel coronary artery disease.
Potential Biases
Potential bias in treatment decision making due to lack of blinding for care providers.
Limitations
Physicians involved in patient care are not blinded to treatment method, which may bias treatment decisions; the study is conducted by a single surgeon, which may limit generalizability.
Participant Demographics
Patients aged 30-90 years with multivessel coronary artery disease requiring first-time CABG with at least three grafts.
Digital Object Identifier (DOI)
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