Impact of Type 2 Diabetes and Metabolic Syndrome on Heart Structure in Men
Author Information
Author(s): Campbell Duncan J, Somaratne Jithendra B, Jenkins Alicia J, Prior David L, Yii Michael, Kenny James F, Newcomb Andrew E, Schalkwijk Casper G, Black Mary J, Kelly Darren J
Primary Institution: St. Vincent's Institute of Medical Research
Hypothesis
Are type 2 diabetes and metabolic syndrome associated with changes in myocardial structure and microvasculature in men with coronary artery disease?
Conclusion
The impaired diastolic function in type 2 diabetic and metabolic syndrome patients is not due to increased myocardial fibrosis or changes in microvascular structure.
Supporting Evidence
- Diabetic and metabolic syndrome patients had higher pulmonary capillary wedge pressure than controls.
- Diabetic patients had reduced mitral diastolic peak velocity, indicating impaired diastolic function.
- Neither diabetic nor metabolic syndrome patients showed increased myocardial interstitial fibrosis.
Takeaway
This study looked at men with diabetes and metabolic syndrome to see how their hearts are affected, and found that their heart problems aren't caused by extra scarring in the heart muscle.
Methodology
Histological analysis of left ventricular biopsies from men undergoing coronary artery bypass graft surgery.
Potential Biases
Selection bias from sampling patients presenting for coronary artery bypass graft surgery.
Limitations
Limited sample size and selection bias due to the need for myocardial biopsies from patients undergoing surgery.
Participant Demographics
46 male patients with coronary artery disease, including 13 controls, 10 with type 2 diabetes, and 23 with metabolic syndrome.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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