Combining Cyclosporine and Erythropoietin Reduces Brain Damage After Stroke in Rats
Author Information
Author(s): Yuen Chun-Man, Sun Cheuk-Kwan, Lin Yu-Chun, Chang Li-Teh, Kao Ying-Hsien, Yen Chia-Hung, Chen Yung-Lung, Tsai Tzu-Hsien, Chua Sarah, Shao Pei-Lin, Leu Steve, Yip Hon-Kan
Primary Institution: Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
Hypothesis
Does combined cyclosporine A and erythropoietin therapy limit brain infarction and improve neurological function in rats after ischemic stroke?
Conclusion
The combined treatment with cyclosporine and erythropoietin was superior to either one alone in protecting rat brains from ischemic damage after stroke.
Supporting Evidence
- Combined therapy significantly reduced brain infarct area compared to control.
- Neurological function improved more with combined therapy than with either drug alone.
- Inflammatory markers were lower in the combined therapy group.
- Apoptotic markers were reduced with combined treatment.
- Cyclosporine and erythropoietin both showed protective effects against ischemic damage.
Takeaway
Giving two medicines together helps rats' brains heal better after a stroke than using just one medicine.
Methodology
Fifty adult male SD rats were divided into five groups to receive different treatments after inducing ischemic stroke.
Limitations
The study only lasted 21 days, and the safety of cyclosporine dosage was not investigated.
Participant Demographics
Adult male Sprague-Dawley rats, weighing 300-325 g.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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