Identifying Errors in Genetic Marker Positions
Author Information
Author(s): Curtis David
Primary Institution: Queen Mary's School of Medicine and Dentistry
Hypothesis
Can allelic association studies reveal errors in marker position assignments in genome wide association data?
Conclusion
The study found that allelic association can help identify markers with incorrect map positions.
Supporting Evidence
- The study screened 7.8*10^10 pairs of markers for allelic association.
- Six markers were identified as having incorrect map positions.
- One marker's position was corrected in a later build.
Takeaway
This study looked at genetic markers to see if they were in the right places on the map, and found some that were not.
Methodology
The study analyzed 396,591 markers in 541 subjects for allelic association using a custom screening procedure.
Limitations
The algorithm for identifying overlapping sets of markers was not perfect, which may have affected results.
Participant Demographics
541 subjects, both cases and controls, involved in a GWA of Parkinson's disease.
Digital Object Identifier (DOI)
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