Vitamin K3 and Vitamin C Induce Apoptosis in Leukemia Cells
Author Information
Author(s): Angelica R Bonilla-Porras, Marlene Jimenez-Del-Rio, Carlos Velez-Pardo
Primary Institution: University of Antioquia (UdeA)
Hypothesis
VK3 and VC might induce cell death in leukemia cells through activation of transcription factors by oxidative stress.
Conclusion
VK3 and VC induce apoptosis in leukemia cells through oxidative stress mechanisms.
Supporting Evidence
- VK3 and VC induced apoptosis in leukemia cells through oxidative stress mechanisms.
- High concentrations of VK3 and VC were more effective in inducing cell death.
- Antioxidants reduced the apoptosis induced by VK3 and VC.
Takeaway
This study shows that vitamins K3 and C can help kill leukemia cells by causing stress inside the cells, leading to their death.
Methodology
The study involved treating leukemia cell lines with VK3 and VC and assessing apoptosis through various biochemical assays.
Limitations
The study was conducted in vitro, and results may not directly translate to in vivo conditions.
Participant Demographics
The study used leukemia cell lines Jurkat and K562, and peripheral blood lymphocytes from healthy adult males.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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