Outbreak of Group A Streptococcus Infections Among Drug Users
Author Information
Author(s): Lorenz M. Bohlen, Kathrin Muhlemann, Olivier Dubuis, Christoph Aebi, Martin G. Tauber
Primary Institution: University of Berne, Berne, Switzerland
Hypothesis
What are the potential sources and risk factors for acquisition of GAS infection among drug users in Berne?
Conclusion
The outbreak of GAS infections among drug users was linked to specific drug purchase habits.
Supporting Evidence
- 19 cases of GAS infection were identified among drug users.
- Comparison with controls showed a strong association with drug purchase habits.
- Most infections were needle abscesses at the injection site.
Takeaway
Some drug users got really sick from a type of bacteria called group A streptococcus because of where they bought their drugs.
Methodology
A case-control study was conducted comparing drug users with GAS infections to healthy controls, using interviews and laboratory analysis.
Potential Biases
There is a potential bias due to the high refusal rate among controls.
Limitations
The study had a high refusal rate among controls, which may affect the results.
Participant Demographics
19 drug users with GAS infections and 55 healthy controls, mostly male, aged 20-48.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI
Statistical Significance
p<0.001
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