Current Advances in Retroviral Gene Therapy
2011
Advances in Retroviral Gene Therapy
publication
Evidence: moderate
Author Information
Author(s): Yi Youngsuk, Jong Noh Moon, Hee Lee Kwan
Primary Institution: TissueGene Inc.
Hypothesis
The study explores safety issues and potential improvements in retroviral gene therapy.
Conclusion
Current retroviral gene therapy methods still pose significant safety risks, particularly regarding insertional oncogenesis.
Supporting Evidence
- Leukemia cases have been reported following retroviral gene therapy, highlighting safety concerns.
- Lentiviral vectors, while safer, still pose risks of clonal dominance and insertional mutagenesis.
- Targeted delivery methods are being explored to improve the specificity and safety of retroviral therapies.
Takeaway
This study looks at how gene therapy using retroviruses can sometimes cause cancer, and suggests ways to make it safer.
Methodology
The review discusses various safety features and improvements in retroviral gene therapy.
Potential Biases
Potential bias in reporting outcomes from previous studies may exist.
Limitations
The review does not provide new experimental data but summarizes existing knowledge and concerns.
Digital Object Identifier (DOI)
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