Understanding Quinolone-Resistant Neisseria gonorrhoeae in Israel
Author Information
Author(s): Pérez-Losada Marcos, Crandall Keith A, Bash Margaret C, Dan Michael, Zenilman Jonathan, Viscidi Raphael P
Primary Institution: Brigham Young University
Hypothesis
Can molecular evolutionary analyses distinguish between the importation and diversification of quinolone-resistant Neisseria gonorrhoeae?
Conclusion
The study shows that quinolone-resistant Neisseria gonorrhoeae were likely introduced into Israel on at least three occasions and have undergone limited diversification.
Supporting Evidence
- Phylogenetic analyses indicated QRNG were introduced on three separate occasions.
- Reconstruction of N. gonorrhoeae demography showed a declining effective strain population size from 1976 to 1993.
- An increase in effective strain population size was observed from 1999 to 2001.
Takeaway
This study looks at how a type of bacteria that resists certain medicines came to Israel and how it changed over time.
Methodology
Molecular evolutionary analyses were applied to DNA sequences from 9 housekeeping genes and resistance genes of 24 quinolone-resistant and 24 sensitive isolates.
Limitations
The small sample size of 48 strains may limit the generalizability of the findings.
Participant Demographics
Isolates were collected from male urethral samples in Tel Aviv, Israel.
Digital Object Identifier (DOI)
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